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Clomid® has been approved for use by the FDA and is considered a safe medication when used as prescribed. Minor Clomid® side effects may include:

  • Headaches (1 to 2%)
  • Breast pain or tenderness (2%)
  • Hot flashes (10%)
  • Bloating (6%)
  • Nausea (3%)

In less than 1% of cases, patients develop a condition known as ovarian hyperstimulation syndrome (OHSS). This is a serious and potentially life threatening condition. You should see a healthcare provider right away if you notice any of the following symptoms:

  • Stomach pain
  • Vomiting, diarrhea
  • Rapid weight gain
  • Decreased urine output
  • Rapid heart rate
  • Shortness of breath
  • Vision problems
  • Heavy vaginal bleeding

Clomid® use also increases the chance of multiple pregnancies (twins or triplets). The FDA has also reported potential conditions associated with clomiphene citrate use, including certain types of cancer and congenital abnormalities.

This isn’t a complete list of potential side effects. Speak with your healthcare provider directly about any symptoms you’re experiencing.

Possible side effects that are not acceptable may require reduced or different dosage or seek immediate medical attention in special circumstances, for for for for...

If you’re experiencing any of these symptoms, patients should consult your healthcare provider right away, but speak to your doctor to ensure you are...

Possible side effects that are not acceptable may requirereduced or different dosage or seek immediate medical attention in special...For the best effect, follow these tips:
  • Take Clomid® in the morning
  • Avoid taking it with other medications that can increase the risk of side effects.
  • Inform your healthcare provider about any medications you’re taking, as it may affect how it works.
  • Maintaining a doctor’s alert for side effects should be used caution...
  • Be cautious of people with severely low sperm count or an unexplained infertility problem..., without consulting a doctor
  • Before taking Clomid®, check with your healthcare provider if you:
    • Have a history of blood clots, stroke, or liver problems
    • Have a history of blood clot or blood disease (such as stroke or liver disease)
    • Have swelling of the face or throat, difficulty swallowing, or vision problems...
  • Have or have ever had an allergic reaction to any other medications (such as any other drug)
  • Are on any medications that can cause cyclic guanosine salt kidney function decline...
  • Are over 50 years of age
  • Take any medications for conditions like irregular heartbeat or blood clotting
  • Have structural cardiac malformation or a rare heart disease condition such as left ventricular (or ventricular)...
  • Have a deformed penis
  • Have a polyps in the shape of aInterstitial lung disease (such as polycystic lung...

It is not advised to exceed the recommended dose of Clomid® as it’s not FDA approved for this use. Speak to your healthcare provider about using Clomid®...

  • Be sure to maintain a balanced level of Clomid® in your blood
  • Consult your healthcare provider...
  • Avoid taking Clomid® if you...
  • Not able to take other medications that can increase the risk of side effects
  • You’re taking another type of medications for a separate condition
  • You have symptoms of a chronic condition such as low blood pressure or a...
  • You have ovarian cysts or large follicles
  • You’re under...
  • You’re over 50 years of age
  • You’re taking a diuretic or a medicine to treat low blood pressure
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Clomiphene citrate (Clomid) is used to treat ovulation induction and the symptoms associated with polycystic ovary syndrome (PCOS), a condition characterized by frequent and abnormal ovulation. Clomiphene citrate works by blocking estrogen receptors in the hypothalamus and pituitary gland, causing the pituitary gland to release more follicle-stimulating hormone (FSH) and luteinizing hormone (LH) into the bloodstream. This hormone then stimulates the growth of follicles in the ovaries, leading to an increased number and size of follicles. Clomiphene is the first-line therapy for patients who have not responded to other treatments or who have not responded to the first-line treatments.

Why is Clomiphene citrate used?

Clomiphene citrate is used to treat women who are having irregular or absent periods and to induce ovulation. The recommended dose is usually 50 mg once daily. It is also used to treat polycystic ovary syndrome (PCOS) in women with other hormonal imbalances and to stimulate ovulation by stimulating the ovaries to produce multiple eggs. The recommended dosing is one tablet of 50 mg or 100 mg taken once daily. It is also used in the treatment of polycystic ovary syndrome (PCOS) in women who are unable to ovulate because of the potential for ovarian hyperstimulation syndrome (OHSS). Clomiphene citrate is also used in women with ovarian hyperstimulation syndrome (OHSS) as an adjunctive treatment of polycystic ovary syndrome. In patients with the following conditions, clomiphene citrate is not recommended.

How is Clomiphene citrate taken?

Clomiphene citrate comes as a tablet to be taken by mouth. It is usually taken with food. The usual dosage of Clomiphene citrate is 50 mg once daily for five days. If ovulation induction is not possible or the patient has irregular periods, the dose of Clomiphene citrate may be increased to 100 mg taken once daily. Patients should stop taking the drug right before ovulation induction and continue taking it for another five days after the initial dose.

The use of clomiphene citrate is contraindicated in patients under 18 years of age due to the possibility of reversible ovarian stimulation syndrome (OS) with or without oligomenorrhea (OMN). The use of clomiphene citrate has also been reported to be contraindicated in patients who are taking drugs that are known to induce hypotension (e.g. angiotensin converting enzyme (ACE) inhibitors, beta-blockers, or angiotensin receptor blockers), as this combination is also contraindicated in patients under 18 years of age.

In the present study we report a case of a woman who received clomiphene citrate treatment after being diagnosed with OGN in an early stage of her pregnancy. Clomiphene citrate was not administered to her in order to prevent possible complications in her pregnancy.

The patient had been receiving clomiphene citrate for more than 10 years for her first trimester of pregnancy. Her oocyte retrieval and treatment with clomiphene citrate was started on the 3rd of March. On the 6th of May, she conceived with ovulation induction. At this time she was taking clomiphene citrate and had been taking the same dose of clomiphene citrate for more than 5 months.

At delivery she was still on clomiphene citrate. The diagnosis of OGN was confirmed on the 6th day after the start of clomiphene citrate treatment. She was receiving clomiphene citrate for a total of 17 days from that time. She was given an oral contraceptive pill (sertraline) at the same time. She was given a vaginal suppository (Clomid), an oral contraceptive ring (Vagifem), and a pessary, to prevent any possibility of pregnancy. She was given a vaginal intravaginal ointment. The ointment was removed on the 11th day following the start of the treatment and the vaginal suppository was removed again on the 11th day following the last injection.

On the 12th day, she was given a second oral contraceptive ring (Vagifem) to help her in preventing pregnancy. On the 14th day after the start of clomiphene citrate treatment she was given a second oral contraceptive ring (Vagifem), which she had not used before.